His best known piece is the "Hand-Chair": a sculpture / chair designed to sit on the palm, using the fingers as a backrest and armrest. Friedeberg started studying architecture but did not finish his studies. He began to produce designs that went against the conventional forms of the 1950s, some as incredible as houses with artichoke-shaped roofs. His work caught the attention of Mathías Goeritz, who encouraged him to continue his artist career. Friedeberg became part of a group of Mexican surrealist artists, including Leonora Carrington and Alicia Rahon, distinguished for their irreverence, rejecting the social and political art that was dominant at the time. Friedeberg has built a reputation for being eccentric and claiming that art has died because nothing new has been produced.